Allergy Research Group®

 Time Release Melatonin (Hypoallergenic)

Allergy Research Group® was the first to introduce Melatonin into the healthfood and professional market.  It has many nutritional benefits including profound antioxidant properties via hydroxy radical scavenging. However, its main function in the body is to support the aspects of brain chemistry involved in sleep.*  Most of the recent work on melatonin has been done by Dr. Russell Reiter, author of "Melatonin - Your Body's Natural Wonder Drug".

Time Release Melatonin is the same as Item ChronoSet and Allergy Research Group®'s other Melatonins, the difference being that this product is a 1.2 mg time release tablet form.  This time release form allows the melatonin to be released slowly into the system over a longer period of time, potentially being particularly beneficial for the aspects of brain chemistry involved in sleep and staying asleep.*

Time Release Melatonin - 1.2 mg - Hypoallergenic - 60 Tablets

Melatonin is a solid, lipophilic, hydrophobic substance, also known as N-acetyl-5-methoxytryptamine. It is the principal hormone of the human pineal gland, and can also be found at much lower concentrations in plants. Melatonin is synthesized by the pinealocytes of the pineal gland. The pathway begins with the amino acid L-tryptophan, which is metabolized to 5-hydroxy-tryptophan ( 5-HTP ), then 5-hydroxytryptamine ( serotonin ), and finally to melatonin. The rate limiting step in the synthesis of melatonin is the N-acetylation of 5-hydroxytryptamine by the enzyme arylalkylamine N-acetyltransferase ( AA-NAT ).

Melatonin is the primary substance that controls entrainment in circadian rhythms, or patterns of wakefulness and sleep. The pineal is a tiny gland located deep in the brain behind the eyes, which monitors the external environment, integrating this information with the internal environment and producing melatonin to regulate the daily cycle. The pineal has nerves that connect it with the retina of the eye, and the primary melatonin receptor is expressed mainly in the retina. The external stimuli of light and darkness cause the pineal to change the rhythm of the enzyme AA-NAT, which then affects melatonin levels. Through this mechanism, melatonin synthesis is stimulated by darkness and inhibited by light. *

Numerous studies suggest that melatonin can be effective for regulation of sleep. Melatonin has been shown to induce sleep in people of all ages. A well-designed study showed that 2 mg daily of melatonin allowed people to replace benzodiazepine with melatonin, maintaining good sleep quality. Melatonin has been used for menopause related insomnia, jet lag, and by night shift workers and the blind. Studies with menopausal women also show benefits for mood. Low melatonin levels in women may correlate with increased breast cancer risk. Preliminary studies show that melatonin may provide adjunctive nutritional support for those with breast cancer and may enhance the effectiveness of some chemotherapy. It may also support the function of the ear in people with ringing in the ears. *

At high doses, melatonin has significant antioxidant activity, including the capacity to inhibit metal ion-catalyzed oxidation processes, specifically the Fenton reaction. Melatonin has also been found to have anti-apoptotic activity in the thymus, as well as in cultured dexamethasone-treated thymocytes, which is a standard model for the study of apoptosis. It is thought to do so by down-regulating the glucocorticoid receptor. Aspirin, other NSAIDs, and beta-blockers may lead to decreased melatonin levels. *

*Hypoallergenic Defined:  According to Taber's Cyclopedic Medical Dictionary "hypoallergenic" is defined as:  "Diminished potential for causing an allergic reaction."   Allergy Research Group® defines hypoallergenic as "Free of all common allergens", specifically, wheat, corn, soy, gluten, yeast, dairy, and eggs. Many very sensitive individuals who reach to supplements in general, are able to tolerate Allergy Research Group® product.  Since our inception in 1979, we have been using only the purest, and whenever possible, the lowest allergy potential natural ingredients.  And while many of the nutrients in our formulas are synthesized from natural substances (plant sources), which as a whole may contain antigens, the synthesizing process removes the molecules of the desired nutrient from the original substance, and in the processing a great percentage of the antigens and allergens are left behind. The final material then has extremely low allergy potential.  This is not to say that no one will react to any of our hypoallergenic formulas, as some extremely sensitive people may.  However, the potential for an allergic reaction is low, and the feedback from many of our extremely allergic and sensitive customers is that Allergy Research Group® supplements are the only products they are able to tolerate.  (For further information about Allergy Research Group, click on their information link above)

*Any statements on Natural Health DOC relating to these products from Allergy Research Group® products have not been evaluated by the Food & Drug Administration. These product from Allergy Research Group ® are not intended to diagnose, treat, cure or prevent any disease.  All Trademarks "™" or Registered Marks "®"on these pages are the sole property of Allergy Research Group®

Disclaimers:
While we carry Allergy Research Group® products, neither A Natural Health Clinic, Inc., Natural Health DOC, or Dr. Linda Hadley nor any third party associated with us, related to or linked to Natural Health DOC, or any other affiliated business or website is in any way affiliated with Allergy Research Group®. Allergy Research Group® expressly disclaims any responsibility for and makes no representations or warranties regarding any statement, information, materials, or content found on or included in Dr. Linda Hadley's marketing materials, website, or any third party marketing materials or websites related to, associated with or linked to Natural Health DOC.

The products and claims made about specific products on their pages or their associated information sheets in or throughout Natural Health DOC or any of its affiliate websites, have not been evaluated by the Food & Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. The information presented in this website is for the purpose of "information only" and is not intended as a substitute for advice from a health care practitioner. Before starting any weight loss program, exercise program, diet, or supplements you should consult with a health care practitioner if you have or suspect you have a health issue.