| Description of UltraIsoFlavones (With Soy Isoflavones) from Allergy Research Group®: Because soybeans are rich in proteins (35%) and their oil is of good nutritional quality and value, they have been utilized dietarily by humans for years. Most East Asian populations consume soybean seeds regularly from childhood via a variety of products typical of their culture. Additionally, vegetarians, who are also at decreased risk for breast and colon cancer, frequently consume soybean-based meat substitutes. * Much research has been conducted to discriminate between the active constituents in the soybean. Of particular interest is the isoflavone group. Isoflavones are a unique subgroup of phytoestrogens, but are also a subgroup of flavonoid compounds called bioflavonoids. The most studied and apparently biologically active compounds are genistein, daidzein, formononetin, and equol, which become activated when intestinal microflora act upon their precursors and create active forms. They are excreted as glucoronide conjugates in both the bile and urine.* In 1954 it was concluded that a dietary constituent, with its origin in soybeans, was responsible for any estrogenic effect in animals. Around this time genistein, the isoflavone found in the highest amounts in soy, was classified as a very weak estrogen (and since this time, daidzein has been labeled a phytoestrogen as well, with bioactive properties similar to genistein). As research continued, isoflavones were shown to act as modulators of endogenous estrogen activity through their affinity for estrogen receptor sites. Thus, they could have either estrogenic and/or anti-estrogenic activity. The latter occurs through competitive inhibition of estrogen receptors.* It was also discovered that at least some of these phytochemical compounds were modified by microbial activity within the intestinal tract, producing the by-products which actually possess the hormonal activity. It is for this reason that the estrogenic effects of the isoflavones are desired in menopausal and perimenopausal nutritional programs: to boost low estrogen levels, and osteoporosis-preventative regimens. Estrogen inhibits osteoclastic activity. * While genistein imparts steroidal effects, it also functions as a tyrosine kinase inhibitor. Genistein, the more well studied of the isoflavones found in soy, also inhibits the topioisomerase II enzyme and can arrest cell-cycle growth in the G2-M phase. Daidzein can arrest the growth in the G1-M phase. * Apart from their apparent hormonally-active roles, inhibition of platelet aggregation secondary to action-blockade of tyrosine kinase activity has been exemplified in models of both thrombin- and vasopressin-mediated aggregation: platelet aggregation may stimulate the process of metastasis. Also important in blocking abnormal cell proliferation is blockade of leukotriene production, hence impacting potential inflammation. * Isoflavones may also inhibit angiogenesis: in one study, a fraction of the urine of healthy subjects who consumed a plant-based diet inhibited the proliferation of vascular endothelial cells and inhibited angiogenesis in vitro. The most potent fractions were isoflavones, of which the most potent was genistein. Isoflavones found in UltraIsoFlavones at concentrations of 24 mg/ml are categorized as follows: 12 mg genistein/genistin. Genistin is genistein with a glucose attached to the flavone. The body readily converts it to genistein. Also: 12 mg daidzein/daidzin. Daidzin is daidzein also with an attached glucose, and the body will convert it to daidzein. * Larger proteins are eliminated by affinity column processing. Relatively low allergenic potential is therefore achieved, with less than 10% soy proteins.* Also found in UltraIsoFlavones is Chinese Blackberry Extract containing 43% terpene glycosides, 16% polyphenols, and 6% flavonoids. This formula was synergistically formulated in accordance with the Universal Harmony Theory. The UHT is another way of expressing the yin/yang balance. The soy isoflavones are potentially allergenic with an unpleasant taste. The Chinese Blackberry contains polysaccharides, polyphenols, and flavonoids which may help with allergic reactions; the sweet blackberry improves the flavor. In Chinese Medicine, soy has generally neutral energy, and on a deeper level, it is slightly warm. The Chinese Blackberry is also generally neutral energetically, however on a deeper level it is slightly cooling. All ingredients are organically grown in the mountains of China. * Allergy Research Group®, Inc. |