Allergy Research Group®

 GlucoTrim® (Formerly Glucosol™) (Hypoallergenic)

GlucoTrim® (Formerly Glucosol™) - Hypoallergenic - 60 Softgels

Here are today's new, innovative and powerful nutrient formulas, that don't yet fit into a 'category'. As always, Allergy Research Group® obtains raw materials from the finest sources and strives to make their products as free of allergens as possible. *

Article about GlucoTrim® (Formerly Glucosol™) (Hypoallergenic) from Allergy Research Group®:

Diabetes has been with us for centuries, dating back to at least ancient Greece. Nowadays it affects 16 million Americans, and it is the fourth leading cause of death, the most common cause of kidney failure, and the principal cause of blindness in adults. Type I diabetes is insulin dependent and affects only 5% of the diabetic population. Type II diabetes, which is non-insulin dependent, usually develops in adults over the age of 40, and is increasingly common. People with Type II diabetes often show no symptoms. It occurs as a result of the decline in cell membrane insulin sensitivity, and is greatly exacerbated by the consumption of refined carbohydrates, lack of exercise, and obesity. *

Traditionally, various medicinal plants from India, China and Japan have been used for the treatment of diabetes. The most effective plant extract is from the tropical botanical Lagerstroemia speciosa L., also known as Queen's flower, Pride of India, and Banaba. The leaf tea or extract has been used for centuries as an aid for blood sugar control, as well as for weight loss. GlucoTrim® is a unique formulation that contains the extract from this tree, from leaves containing high levels of corosolic acid, the active ingredient. *

Cellular Uptake of Glucose:

Dr. Yamazaki, professor of Pharmaceutical Science, Hiroshima University School of Medicine, Japan, has studied corosolic acid. His studies indicate that corosolic acid can help reduce blood sugar levels by activating the transport of glucose across cell membranes; in short, corosolic acid has an insulin-like effect. Glucose transporters are important in regulating the level of intracellular glucose. *

Insulin injections are dose-critical and can produce adverse reactions, whereas oral doses of corosolic acid have no known side effects. Corosolic acid, when given orally to rabbits, had a similar effect as subcutaneous injections of insulin. This insulin-like effect of Corosolic acid causes it to be dubbed a "phyto-insulin". *

Pre-clinical studies:

Glucose transport is a key function involved in the cellular production of energy. Glucose transport through the cell membrane facilitates the lowering of blood sugar, so assisting glucose transport is important for Type II diabetics. Ehrlich ascites tumor cells are used to screen the glucose transport potential of natural products. In one study that used Ehrlich cells to measure glucose uptake, corosolic acid showed significant glucose transport-stimulating activity. *

The sugar-lowering effect of corosolic acid was then studied in hereditary Type II diabetic mice. For five weeks, one group of mice was fed a control diet while the other group was given a diet that included corosolic acid. The blood glucose levels increased in the control group but were suppressed in the mice eating the corosolic acid diet. In this experiment, crossover of the diet between the two groups yielded results consistent with the above observation. In another experiment, Type II diabetic rats given corosolic acid showed decreased blood sugar levels, whereas the control group had higher blood sugar levels. The rats supplemented with corosolic acid also showed lower serum insulin, urinary excreted glucose and total plasma cholesterol.*

In another study using normal rabbits that had fasted, the administration of a large oral dose of corosolic acid produced blood sugar reductions similar to the effects of two units of insulin. Another dose of corosolic acid two hours later caused the blood sugar to remain low or go even lower. The peak reduction occurred 2-4 hours after the corosolic acid was given, with blood sugar returning to normal in 6-10 hours. Researchers in Italy and Japan conducting animal studies confirm that corosolic acid can cause significant and immediate blood sugar reduction. *

Human Studies:

In 1998, a crossover, placebo-controlled clinical study was conducted at the Tokyo Jikeikai Medical School in Japan with 24 Type II diabetic human subjects. After four weeks, corosolic acid was shown to effectively reduce blood glucose levels vs. placebo, with no adverse effects. Furthermore, even a one-time dose left a "memory-effect" for blood glucose control, lasting several days. In another study conducted at the Southwestern Institute of Biomedical Research, in Brandenton, Florida, 12 human subjects with mild Type II diabetes were studied for 22 weeks. Several forms of corosolic acid were administered to different groups, and in several dosages. It was seen that the higher the dose of corosolic acid, the greater the drop in blood glucose levels. The greatest blood glucose reduction was obtained using an oil-based soft gelatin capsule formulation of corosolic acid at a 48 mg daily dose. *

In an elaborate cross-over study, 12 subjects took a placebo for two weeks, then a daily dose of 48 mg corosolic acid (two oil-based softgels of 8 mg after each meal), for 30 days. This was followed by a 45-day placebo washout period. Then the same group took 48 mg corosolic acid in a different form (two hard gelatin capsules of 8 mg corosolic acid dry powder after each meal), for 30 days. Another 45 day washout followed. The results show that corosolic acid is effective in reducing blood glucose levels, with no adverse effects. *

Specifically, the average blood glucose level in the control group was 168.3 mg/deciliter. The soft gelatin formulation of corosolic acid caused a rapid drop to an average value 115.1 mg/deciliter at the 30th day of corosolic acid treatment. During the washout period, the blood glucose level only slowly came back up, suggesting a memory effect of corosolic acid for up to four weeks after the termination of intake. Also, 48 mg of corosolic acid per day continued to reduce blood glucose levels until the end of the 30-day period. *

Additional benefits were seen, with corosolic acid restoring a normo-glycemic profile after meals. The corosolic acid group had a normal sharp decline in blood glucose levels after eating, compared to the slow decline after a meal often seen in diabetics. The diabetic symptoms of frequent thirst and urination also disappeared for those using the corosolic acid, and there was an increased ability to lose weight. This U.S. clinical study confirms the 1998 Japanese clinical study showing that corosolic acid safely and effectively lowers blood glucose levels in Type II diabetics. *

Final Words:

GlucoTrim® corosolic acid is clinically proven to activate cellular glucose transport, which can help balance blood glucose levels. GlucoTrim® can show a memory effect of blood glucose lowering even after the treatment is stopped. By controlling blood sugar, GlucoTrim® helps maintain low blood pressure and normal kidney function, thus preventing damage to blood vessels and kidneys. GlucoTrim® also delivers antioxidant activity as strong as Vitamin E, which can protect cell membranes from lipid peroxidation by scavenging free radicals. These antioxidant effects are currently being studied, as well as the ability to lower blood pressure, aid kidney function and to protect against the toxic glycosylation resulting from elevated serum glucose. Finally, it has been proven that the most effective formulation of corosolic acid known is oil-based in a soft gelatin capsule: GlucoTrim®. *

Allergy Research Group®, Inc.

*Hypoallergenic Defined:  According to Taber's Cyclopedic Medical Dictionary "hypoallergenic" is defined as:  "Diminished potential for causing an allergic reaction."   Allergy Research Group® defines hypoallergenic as "Free of all common allergens", specifically, wheat, corn, soy, gluten, yeast, dairy, and eggs. Many very sensitive individuals who reach to supplements in general, are able to tolerate Allergy Research Group® product. Since our inception in 1979, we have been using only the purest, and whenever possible, the lowest allergy potential natural ingredients. And while many of the nutrients in our formulas are synthesized from natural substances (plant sources), which as a whole may contain antigens, the synthesizing process removes the molecules of the desired nutrient from the original substance, and in the processing a great percentage of the antigens and allergens are left behind. The final material then has extremely low allergy potential. This is not to say that no one will react to any of our hypoallergenic formulas, as some extremely sensitive people may.  However, the potential for an allergic reaction is low, and the feedback from many of our extremely allergic and sensitive customers is that Allergy Research Group® supplements are the only products they are able to tolerate.  (For further information about Allergy Research Group, click on their information link above)

*Any statements on Natural Health DOC relating to these products from Allergy Research Group® products have not been evaluated by the Food & Drug Administration. These product from Allergy Research Group ® are not intended to diagnose, treat, cure or prevent any disease.  All Trademarks "™" or Registered Marks "®"on these pages are the sole property of Allergy Research Group®

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While we carry Allergy Research Group® products, neither A Natural Health Clinic, Inc., Natural Health DOC, or Dr. Linda Hadley nor any third party associated with us, related to or linked to Natural Health DOC, or any other affiliated business or website is in any way affiliated with Allergy Research Group®. Allergy Research Group® expressly disclaims any responsibility for and makes no representations or warranties regarding any statement, information, materials, or content found on or included in Dr. Linda Hadley's marketing materials, website, or any third party marketing materials or websites related to, associated with or linked to Natural Health DOC.

The products and claims made about specific products on their pages or their associated information sheets in or throughout Natural Health DOC or any of its affiliate websites, have not been evaluated by the Food & Drug Administration and are not intended to diagnose, treat, cure, or prevent any disease. The information presented in this website is for the purpose of "information only" and is not intended as a substitute for advice from a health care practitioner. Before starting any weight loss program, exercise program, diet, or supplements you should consult with a health care practitioner if you have or suspect you have a health issue.