Allergy Research Group®

 Full Spectrum Vitamin K™ (Hypoallergenic)

Full Spectrum Vitamin K™ - Hypoallergenic - 90 Softgels

Full Spectrum Vitamin K™ is a comprehensive Vitamin K formula that contains Vitamin K1, two forms of Vitamin K2, and other fat-soluble antioxidant cofactors, such as Vitamins A, D and E (as gamma and delta tocotrienols).  Vitamin K is a generic term for a group of substances which contain the 2-methyl-1, 4-naphthoquinone ring structure.  These substances support healthy coagulation properties (the term 'vitamin K' derives from the German word 'koagulation'.)*  In addition to its antihemorrhagic activity, Vitamin K is involved in bone metabolism, the cardiovascular system,, and antioxidant activity. *

Vitamin K1 (phylloquinone) is found in green leafy vegetables and some vegetable oils.  Forms of Vitamin K2 (menaquinones) are found in egg yolk, butter, liver and some other foods, and can also be produced by friendly bacteria in the gastrointestinal (GI) tract.  (Vitamin K3 or menadione is a synthetic compound used in animal feed.)  All forms of Vitamin K are fat-soluble.  The forms of Vitamin K2 (menaquinones) are characterized by the number of isoprene residues that make up the characteristic side chain, and are designated by the number of isoprene residues in the structure.  For instance, menaquinone-4 (MK-4) possesses four isoprene residues in the side chain, and MK-7 has seven isoprene units. *

 Vitamin K, especially in the form of K2, helps calcium to get into the blood and bones where it belongs, and studies indicate that it potentially supports both bone mineral density and vascular elasticity within normal levels.*  Vitamin K is required for the gamma-carboxylation of glutamyl residues on many bone and other proteins.  Gamma-carboxylation is catalyzed by the Vitamin K-dependent gamma-carboxylases.  When Vitamin K is in short supply in the body, these proteins are formed without the gamma-carboxy glutamic acid (GCGA) component.*

The tissues of the liver, bones, cartilage and arterial vessel walls all receive Vitamin K from the blood.  However, the uptake into the liver is much greater than for other tissues, and it appears that the liver's production of clotting factor takes priority over other Vitamin K-dependent processes.  The current dose recommendations for Vitamin K are based solely on the liver's requirements. The enzymes that do not receive GCGA because of a Vitamin K1 or K2 deficiency will be under-carboxylated and unable to support proper calcium metabolism.*  This may not be optimal for the bones, the cardiovascular system and the cartilage.*

According to the Food and Nutrition Board of the National Academy of Sciences National Research Council, the requirements of Vitamin K ranges from 5 micrograms for infants, up to 80 mcg for adult males and 65 mcg for adult females.  However, in November 2002, a number of European experts in the fields of Vitamin K research, bone metabolism and cardiovascular function met to review all the available scientific data on dietary and supplemental Vitamin K.  They concluded that for optimal bone and vascular health, daily intake of between 200 and 500 mcg/day of Vitamin K through food sources may be required for optimal health.*

In vitro studies have demonstrated that Vitamin K2 inhibits the production of bone resorbing substances, including prostaglandin E2 and interleukin-6.*  In vitro and animal studies indicate potential enhancement of osteoblast-induced mineralization.*  Besides Vitamin K, optimum calcium nutrition depends on the interplay of a number of related compounds, including magnesium and Vitamin D3.*

Research also shows that Vitamin K has antioxidant activity comparable to Vitamin E and CoQ10.*  In addition, animal studies in Japan found that Vitamin K potentially supports blood sugar within normal levels.  The pancreas contains the second highest concentration of Vitamin K in the body.*

The absorbability of K2 from GI tract bacteria is uncertain, and the absorption of K1 from vegetables can be as low as 10%. Both K1 and K2 are well absorbed from supplements as long as they are taken with some dietary fat to stimulate bile secretion. Intakes up to 1 mg/day of K1 and 45 mg/day of Vitamin K2 have been used with no observed side effects.  Supplemental Vitamin K has no hemostatic activity in those who are not Vitamin K-deficient.*

Precautions: High levels of Vitamin K supplementation may interfere with oral anticoagulant medications such as warfarin, which are antagonists of Vitamin K. Those taking oral anticoagulant treatment should not use Vitamin K supplements, unless specifically prescribed by their healthcare practitioner. Pregnant women and nursing mothers should not take more than RDA amounts (65 micrograms daily) unless higher amounts are prescribed by their healthcare practitioner. This product should not be taken at the same time as cholestyramine, colestipol, mineral oil, orlistat, salicylates, olestra and squalene.*

Allergy Research Group®, Inc.

*Hypoallergenic Defined:  According to Taber's Cyclopedic Medical Dictionary "hypoallergenic" is defined as:  "Diminished potential for causing an allergic reaction."   Allergy Research Group® defines hypoallergenic as "Free of all common allergens", specifically, wheat, corn, soy, gluten, yeast, dairy, and eggs. Many very sensitive individuals who reach to supplements in general, are able to tolerate Allergy Research Group® product. Since our inception in 1979, we have been using only the purest, and whenever possible, the lowest allergy potential natural ingredients. And while many of the nutrients in our formulas are synthesized from natural substances (plant sources), which as a whole may contain antigens, the synthesizing process removes the molecules of the desired nutrient from the original substance, and in the processing a great percentage of the antigens and allergens are left behind. The final material then has extremely low allergy potential. This is not to say that no one will react to any of our hypoallergenic formulas, as some extremely sensitive people may.  However, the potential for an allergic reaction is low, and the feedback from many of our extremely allergic and sensitive customers is that Allergy Research Group® supplements are the only products they are able to tolerate.  (For further information about Allergy Research Group, click on their information link above)

*Any statements on Natural Health DOC relating to these products from Allergy Research Group® products have not been evaluated by the Food & Drug Administration. These product from Allergy Research Group ® are not intended to diagnose, treat, cure or prevent any disease.  All Trademarks "™" or Registered Marks "®"on these pages are the sole property of Allergy Research Group®

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