Allergy Research Group®

 Super D3 (Contains Vitamin E Derived From Soy)

Super D3 (Contains Vitamin E Derived From Soy) - 60 Capsules

Vitamin D3 is an essential vitamin.  In fact, it acts as a hormone precursor as it requires two stages of metabolism before reaching actual hormonal form.  Following absorption or endogenous synthesis, it is metabolized to 25-hydroxycholecalciferol (25(OH)D) in the hepatocytes.  25(OH)D is the major circulating form of Vitamin D, but not biologically active.  Second, the biologically active hormone form, 1 alpha, 25-dihydroxycholecalciferol (1,25(OH)2D) is produced in the kidney.

A high prevalence of Vitamin D deficiency has been reported in numerous studies.  This deficiency is common in much of the world, in the young and old.  Why is Vitamin D deficiency so prevalent?  Basically, because there is limited exposure to sunlight, and dietary intake of Vitamin D is inadequate. *

Many researchers who documented a high prevalence of Vitamin D deficiency have recommended dietary Vitamin D supplementation. *

The Reference Daily Intake (RDI) for Vitamin D is 400 IU.  This value is used on nutritional supplement and food labels. Because Vitamin D can cause toxicity, the U.S. National Academy of Sciences has presented a new standard, the tolerable upper limit intake level (UL):  infants (0 through 12 months) - 1000 IU/day, children and adults, including pregnant and lactating women - 2000 IU/day.  Some researchers argue that current recommendations are inadequate and should be at least ten times higher. *

Vitamin D is the principal regulator of calcium homeostasis in the body.  It is essential for skeletal development and bone mineralization.  Vitamin D deficiency is the cause of rickets in children and osteomalacia in adults.  Furthermore, Vitamin D deficiency in adults can lead to osteoporosis.  A number of studies have reported significant benefits from supplemental Vitamin D in the prevention and treatment of osteoporosis.  Others have observed that Vitamin D deficiency can also result in muscle weakness, another possible contributor to falls and fractures. *

Along with the classic role of Vitamin D in regulation of bone mineralization and serum calcium levels, it has been recognized to play an important role in cell differentiation and proliferation.  This led to Vitamin D being considered as an important factor in cancer prevention and therapy and to a substantial number of studies investigating the effect of 1,25(OH)2D3 on cancer cells.  The results are encouraging.  Laboratory, animal and epidemiological evidence suggest that Vitamin D and its analogues may be protective against breast, prostate, skin and colon cancer. *

It has been proposed that Vitamin D may also protect against diabetes.  Vitamin D deficiency is strongly associated with glucose intolerance. *

The importance of sunlight and Vitamin D-rich diet for treating tuberculosis was well known in the pre-chemotherapy era.  The active form of Vitamin D has been found to suppress the intracellular growth of Mycobacterium tuberculosis.  Vitamin D supplementation in high-risk populations has been suggested for consideration as preventive therapy. *

Current research suggests that a broad range of additional indications may eventually emerge, including multiple sclerosis, infertility, heart disease and psoriasis. *

References available upon request.

Allergy Research Group®, Inc.

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